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Clopidogrel Bisulfate Tablet

Mylan


$0.63 - $15.36


Strength
Size
Quantity:

$0.63 Each

Detailed Description

Clopidogrel
(kloe-pid-oh-grel)
  • Description: Platelet Aggregation Inhibitor
  • Other Names forthis Medication: Plavix®
  • Common Dosage Forms: Veterinary: None.

 

Clopidogrel is a thienopyridine class, antiplatelet drug. The human trade name is Plavix. It is commonly used in human medicine for stroke patients and those at risk for myocardial infarction due to thrombus formation. Ticlopidine is also a thienopyridine drug, but is less commonly used in veterinary medicine due to a higher incidence of adverse effects when compared to clopidogrel.

Uses/Indications:

Clopidogrel, a platelet aggregation inhibitor, may be useful for the prevention of thromboembolic disease in cats and dogs. 

  • Clopidogrel appears to reduce recurrent cardiogenic arterial thromboembolism and mortality in cats when administered after arterial thromboembolism.
  • Although aspirin and clopidogrel have been used together, evidence supporting the combination of these drugs is scarce. 
  • Clopidogrel may also improve pelvic limb circulation in cats after a cardiogenic embolic event via a vasomodulating effect secondary to inhibition of serotonin release from platelets.
  • Clopidogrel may interfere with the metabolism of NSAIDs ,phenytoin, toresemide, and warfarin.
  • There may be an increased risk of bleeding when clopidogrel is used NSAIDs, warfarin, and aspirin.

In dogs, clopidogrel appears to prevent arterial thromboembolism. This drug may also be effective in dogs with immune-mediated hemolytic anemia (IMHA), although there is not much evidence supporting this use.

Clopidogrel inhibits platelet function in healthy adult horses but failed to attenuate ex vivo equine herpesvirus (EHV)-1 induced platelet activation.

Key Information:

  • Clopidogrel may be given with or withoutfood.
  • If your animal vomits or acts sick after receiving the drug on an empty stomach, try giving the next dose with food or a small treat.
  • If vomiting continues, contact your veterinarian.
  • Bleeding is notlikely but can occur.
  • If your animal shows any signs of bleeding, bruising, or black, tarry stools, consult your veterinarian immediately.

Prescriber Highlights:

  • Oral, once-daily platelet aggregation inhibitor that may be useful in the treatment of dogs and cats with hypercoagulable states and in the prevention of thromboembolic disease.
  • Inhibits platelet function for the lifespan of the platelet; normal hemostasis is typically restored 5 to 7 days after discontinuation of the medication.
  • Appears to be well tolerated, but can potentially cause vomiting or bleeding.

Dogs and Cats:

Clopidogrel is an oral antiplatelet-drug that is used in cats with cardiomyopathy, and in dogs with underlying hypercoagulability. Studies in the cat have shown it to have significant anti-platelet drug activity at a wide range of dosages. It is particularly useful in animals that are unable to tolerate aspirin. Although treatment of pre-clinical hypertrophic cardiomyopathy (HCM) remains controversial, there are many clinicians who use clopidogrel and other cardiac drugs in the asymptomatic cat with HCM.

Clopidogrel is used in dogs for the treatment of immune-mediated hemolytic anemia. Although there are multiple reports regarding its use in the dog, there is not as much clinical experience in the dog as in the cat.

Side Effects:

Clopidogrel is generally well tolerated in the cat. The most commonly-reported side effects are nausea and anorexia. These side effects may be lessened by administration with food.

Precautions:

Extrapolating from the precautions in human medicine would indicate that clopidogrel should not be used in animals with active bleeding. There is no specific precautionary information available for cats and dogs.

Overdose:

  • There is a wide margin of safety for clopidogrel. Based on experience in human medicine, bleeding and vomiting are the most likely clinical signs of overdose.
  • Platelet transfusion may be considered in an acute overdose.

For more information Download and Print Veterinary Medication Guide

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